Fast heartbeat. and animal studies suggest that carbapenems may inhibit the hydrolysis of Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Digestive Disorders: Common Misconceptions. What is meningitis and what causes it? The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Merrem (meropenem) may make you feel weak or confused. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and Read the entire detailed patient monograph for Merrem IV (Meropenem). However severe cases of pneumonia require medical attention especially viral pneumonia. These may be encountered; Pain at the site of injection. When taking Merrem (meropenem), you might experience stiff muscles or abnormal muscle movements. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Additional systemic adverse events that were reported with MERREM IV and occurring in less than or equal to 1.0% but Serious reactions rarely may occur such as: Serious hypersensitivity (allergic) reactions may occur. Probenecid competes with meropenem for active tubular secretion, resulting in increased plasma concentrations of meropenem. Transiently elevated liver enzymes were the most common side-effect. Bacteria cannot survive without a cell wall. MERREM IV. Side effects of Merrem include: nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. A second infection may happen. Bluish lips or skin. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. … You are encouraged to report negative side effects of prescription drugs to the FDA. decreasing the serum concentrations of valproic acid. Mild pneumonia may be healed by body’s defense system. Do not drive or operate heavy machinery until … MERREM IV. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. Common side effects of meropenem include diarrhea, nausea and vomiting, and headache. Although not all of these side effects may occur, if they do occur they may need medical attention. It is unknown if Merrem IV enters breast milk. These are the most common side effects, but there may be others. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Swelling and redness at the injection site. soreness, redness, or swelling at the injection site. See additional information. Adverse events with an incidence of greater than 1%, and not listed above, include: pharyngitis, accidental injury, gastrointestinal disorder, hypoglycemia, peripheral vascular disorder, and pneumonia. Does Merrem IV (meropenem injection) cause side effects? The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. 1. What are the important side effects of Merrem IV (meropenem injection)? valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus Meningitis is an inflammation of the membrane (meninges) surrounding the brain and spinal cord and is characterized by an abnormal number of white blood cells in the cerebrospinal fluid. Additional systemic adverse events that were reported with Merrem IV and occurring in less than or equal to 1.0% but dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. Description: Meropenem is a β-lactam antibiotic.It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Nausea 6. E. coli spreads from person to person via contaminated food or Complicated Skin and Skin Structure Infections The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with considered. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. It is administered intravenously. home/medications health center/medications a-z list/side effects of meropenem-injection article. The following adverse reactions have been identified during post-approval use of Merrem IV. Symptoms may vary depending on the strain the individual contracts. seizure, nervousness, paresthesia, hallucinations, somnolence, anxiety, Upset stomach , headache , nausea , vomiting , constipation , or diarrhea may also occur. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate What are the possible side effects of meropenem? By continuing to browse this site you are agreeing to our use of cookies. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. It kills bacteria that are resistant to other antibiotics. Symptoms and signs include cough, fever, shortness of breath, and chills. Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 595-3300. Anemia If experienced, these tend to have a Less Severe expression 1. MERREM IV was studied in 200 neonates and infants less than 3 months of age. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). If … E. coli can cause urinary tract and bladder infections, or lead to sepsis. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, If it affects only a certain lobe of a lung it's termed lobar pneumonia. {{configCtrl2.info.metaDescription}} This site uses cookies. Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. See additional information. Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. fainting. Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. Major & minor side effects for Meropenem. Abdominal pain. (Meropenem) side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria, including E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and others. hemoperitoneum (0.2%). depression, asthenia, Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. MERREM IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. If experienced, these tend to have a Severe expression 1. Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; nausea; redness, pain, or swelling at the injection site; burning or tingling in the hands or feet; confusion; Some side effects can be serious. Below is a summary of known side effects for MERREM IV. It is not known whether this drug is excreted in human milk. Skin reactions. The most common adverse events occurring in greater than 5% of the patients were: headache (7.8%), nausea (7.8%), constipation (7.0%), diarrhea (7.0%), anemia (5.5%), and pain (5.1%). Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Adverse Reactions. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, Our Merrem IV Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Nausea and vomiting. Adverse effects. Headache 5. Please report all side effects to the doctor or nurse. It is unknown if Merrem IV enters breast milk. Meropenem Side Effects: Common, Severe, Long Term - Drugs.com There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. E. coli is an infection found worldwide. The following adverse reactions have been identified during post-approval use of MERREM IV. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. In the MERREM IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with MERREM IV. drugs a-z list Decreased urine output. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Diarrhea 4. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with Merrem IV (500 mg or 1 gram every 8 hours). Pneumonia may be contagious for 2-14 days. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Pneumonia can be deadly. Safe and effective use of Merrem IV is not established in pregnant females. There are several subtypes of the E. coli Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. There are many types of E. coli (Escherichia coli). Meningitis is inflammation of the membranes that cover the spinal cord and brain. Infection is spread generally through contaminated food or drink. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Merrem IV. somnolence, anxiety, depression, asthenia [see WARNINGS AND PRECAUTIONS], Respiratory: respiratory disorder, dyspnea, pleural effusion, asthma, cough increased, lung edema, Skin and Appendages: urticaria, sweating, skin ulcer, Urogenital System: dysuria, kidney failure, vaginal moniliasis, urinary incontinence. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. water. 6 Several studies have indicated that the most important factor governing the neurotoxicity of a carbapenem is the concentration achieved in the brain tissue. Swelling at the injection site. Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. CLINICAL PHARMACOLOGY]. Local adverse events that were reported with Merrem IV were as follows: Systemic adverse events that were reported with Merrem IV occurring in greater than 1.0% of the patients were. Pneumonia Vaccination: Who Should Have One? Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Most people who take Merrem (meropenem) usually have few side effects. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Pediatric Patients with Serious Bacterial Infections (excluding Bacterial Meningitis): Merrem IV was studied in 515 pediatric patients (3 months to less than 13 years of age) with serious bacterial infections (excluding meningitis, see next section) at dosages of 10 mg/kg to 20 mg/kg every 8 hours. confusion. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with MERREM IV (500 mg or 1 gram every 8 hours). Vomiting Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Antibiotics treat E. coli infection. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Meropenem was administered to treat Escherichia coli for 3 days through an IV in hospital - noticed loosening of stools gaseous stomach and some headaches - but … Merrem IV prevents bacteria from forming the walls that surround them. Meninges act as a protective layer to the brain and spinal cord. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased cold, clammy skin. Get our free fact sheet. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Check with your doctor or nurse immediately if any of the following side effects occur: Less common. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Serious adverse effects are rare. Meropenem can also affect your neurological (brain) function, which can cause dizziness, fainting, or seizures. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. Safe and effective use of Merrem IV is not established in pregnant females. Local adverse events that were reported with MERREM IV were as follows: Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were Symptoms include severe abdominal pain and bloody diarrhea. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Serious side effects of Merrem IV include. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Usually, the goal of medications given for pneumonia is to limit the spread of the disease. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea A severe and sometimes deadly reaction has happened. Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. Read the entire FDA prescribing information for Merrem IV (Meropenem). Meropenem and vaborbactam injection may cause side effects. Constipation 3. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Terms of Use. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. If any of these effects last or get worse, tell your doctor or pharmacist promptly. severe stomach pain, diarrhea that is watery or bloody; sores or white patches in your mouth or throat (yeast infection or "thrush"); nausea, vomiting, diarrhea, constipation; Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid [see, Clostridium difficile – associated Diarrhea [see, Development of Drug-Resistant Bacteria [see, Overgrowth of Nonsusceptible Organisms [see. Merrem IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. View Meropenem’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. One patient treated with imipenem/cilastatin experienced a seizure during the study, while another patient treated with meropenem withdrew due to urticaria. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. Merrem IV is necessary, then supplemental anti-convulsant therapy should be Diarrhea. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. home Co-administration of probenecid with meropenem is not recommended. Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. This is not a complete list of side effects and others may occur. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Bacterial Infections 101 Pictures Slideshow, E. coli 0157:H7 (Escherichia coli 0157:H7), E. Coli Outbreaks in Potato Salad and Wading Pool. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Skin rash. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. chills. Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Fever. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Should I Get the Pneumonia Vaccine Every Year? Merrem IV (meropenem injection) side effects list for healthcare professionals. patients with moderately severe renal impairment (creatinine clearance 10 to 26 What to … Visit the FDA MedWatch website or call 1-800-FDA-1088. (1.3%), shock (1.2%), and pruritus (1.2%). In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. It is unknown if Merrem IV enters breast milk. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. It should be used during pregnancy only if clearly needed. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Bleeding events were seen as follows: gastrointestinal hemorrhage (0.5%), melena (0.3%), epistaxis (0.2%), If administration of leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). A Skin Rash 2. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes.